Drug Discovery Programs & Areas of Interest

Cardiovascular

  • PCSK9 Small Molecule Inhibitors – R&D Collaboration 2015, Out-licensed 2016

Metabolic

  • GLP-1 / GLP-1 Receptor

CNS

  • APOE4

Autoimmune

  • TNF Signaling
  • Interleukin Signaling (IL1, IL6, IL23)

Oncology

  • CTLA4
  • PD-1 / PD-L1
  • Androgen Receptor

Pain

  • CGRP
  • NGF

Infectious Disease

  • Clostridium Difficile
  • Structure base inhibition mechanisms of multi-drug resistance